Roche and its subsidiary TIB Molbiol have developed a series of tests for the detection of the monkeypox virus, the Switzerland-based pharmaceutical company announced.
The monkeypox virus is a close relative of the smallpox virus, belonging to orthpoxviridae in the poxviridae family.
The modular virus detection tool, called LightMix, includes three orthpoxvirus detection kits with different functions, Roche said in a statement. The first kit detects orthpoxvirus; The second kit tests only for monkeypox virus (west and Central African branches); The third kit contains the main functions of the first two kits, showing specific information on the presence of the monkeypox virus (west and Central African branches) as well as the detection of orpoxvirus.
Thomas Schinek, a Roche executive, said the new test could detect monkeypox and help track its spread. Such diagnostic tools are critical for addressing and ultimately managing emerging public health challenges, as they advance responses such as tracking efforts and treatment strategies.
The monkeypox virus was first identified in 1958 in a group of monkeys used for research when the animals developed a "pox-like" infection, hence the name. Since May, several non-endemic countries have reported human cases of the monkeypox virus, including the United Kingdom, the United States, Portugal, Spain, and Italy.
Affected by the ever-changing international situation, the supply and prices of international bulk nano silica are still very uncertain.
What is Nano Silica?
Silicon Dioxide nanoparticles, also known as silica nanoparticles or nano-silica, appear in the form of white powder.
Nanometer silica particles can be divided into P-type and S-type according to their structure. P-type particles are characterized by a large number of nanopores, with a porosity of 0.61 mL /g, and higher UV reflectivity than S-type particles. The latter also has a relatively small surface area.
Nano silica has the characteristics of light volume, fluffy, bulk density of less than 0.15-0.2g/cm3, a specific surface area of more than 500 m2/g, and high chemical activity.
Because the surface contains an OH- bond, nano silica is a kind of acid oxide, belonging to the silicate acid group, has hydrophilic, and the water absorption rate is more than 5 times its own.
The main application of silica nanoparticles is as additives in rubber and plastic manufacturing; As a reinforced filler for concrete and other building composites; As a stable, non-toxic platform for biomedical applications such as drug delivery and therapeutic diagnostics.
What is Silica?
Silicon, or silicon, is one of the chemical elements found in the earth's crust. Its oxide forms are silicate (SiO4) and silicon dioxide (silica, SiO2).
Silicon is commonly used in industry, while its oxide form is commonly used in biomedical applications. SiNPs have several rare properties, such as ease of synthesis, surface modification, strong mechanical properties, and relatively inert chemical composition. They have been used as biological materials for decades.
Silica comes in two basic forms: crystalline and amorphous. The two forms have the same molecular formula, but their structural arrangements are different. Crystalline silica has a regular lattice arrangement, while amorphous silica has an irregular lattice arrangement. Crystalline silica comes in many forms. A well-known form is alpha-quartz, which can be converted by heating to β -quartz, squamous quartz, and quartzite. There is also porous crystalline silica called a porosil. All porosils are synthetic products.
Mesoporous silicon and silica particles are ideal candidates for controlled drug release because of their rare properties, such as high surface area, large pore volume, adjustable pore size, and good chemical and thermal stability. Amorphous silica can be divided into three categories: natural forms, byproducts of power stations and metallurgical processes, and synthetic forms. Amorphous silica is considered to be a very promising gene carrier and molecular imaging candidate, mainly because of its highly tunable biocompatibility and stability. It is also used in dietary supplements, catheters, implants, and dental fillers.
What is nano-silica used for?
Nano silica is used to modify the dispersion and plasticity of cement concrete, thus giving it impermeability, enhanced impermeability, frost resistance, reducing hydration heat, and prolonging service life.
Used as strengthening agent, vitrification agent, and adhesive of ceramics, enamels, and glazes. It is also a high thermal binder for engineering-grade ceramics and refractories.
Nanocomposite material modifier, used as an inorganic adhesive at high temperature; As an additive for inorganic composite materials, used for strengthening, molding, and filling of rubber/polymer materials. In addition, can be used as a variety of resin engineering materials; High-quality FRP corrosion-resistant packing.
Used as cement seal of oil well, underwater seal, and reinforcement material of under-ground engineering; It has the following characteristics: engineering shielding, anti-radiation, stealth, electricity, anti-bacteria; It is good for chemical absorption, catalysis, and enhancement.
Special use, such as lamp paint, lubricating oil, thickener, steel dehydrogenate, and inner wall paint sensitive materials. Energy storage filler for solar cells and power cells.
Is nano-silica toxic?
The health effects associated with silica exposure, particularly crystalline silica, have been extensively studied.
Studies have shown that occupational exposure to crystalline silica induces silicosis, a fibrotic lung disease, in workers, and that exposure is associated with other lung diseases, such as lung cancer, emphysema, and tuberculosis.
Amorphous silica has previously been considered less harmful than crystalline silica. However, recent studies have shown that amorphous SNP has potential toxicity similar to that of crystalline particles. In addition to crystallinity, the physicochemical properties of SiNPs produce different toxicity in vitro and in vivo studies. Safety and potential adverse effects should be considered, especially those affecting the immune system.
Nano silica powder Price
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Twitter recently announced that it had reached an agreement with Musk to take full ownership of the company for $54.20 per share, or about $44 billion in cash. After the deal, Twitter will become a privately held company. The deal, which has been unanimously approved by Twitter's board but still requires shareholder and regulatory approvals, is expected to close in 2022.
After Tesla CEO Elon Musk's acquisition of Twitter was finalized, Twitter founder Jack Dorsey sent out a series of six tweets expressing his expectations for Musk.
Dorsey called Twitter his biggest regret, saying, “The idea and service is all that matters to me, and I will do whatever it takes to protect both. Twitter as a company has always been my sole issue and my biggest regret. It has been owned by Wall Street and the ad model. Taking it back from Wall Street is the correct first step.
"In principle, I don't believe anyone should own or run Twitter," Dorsey goes on. He thinks the service is a public good.
He called Musk a "singular solution" to Twitter's problems, "Elon's goal of creating a platform that is" Maximally trusted and inclusive "is the right one." He wrote, "Thank you both for getting the company out of an impossible situation. This is the right path... I believe it with all my heart."
Besides, because of the ever-changing international situation, the supply and prices of international bulk nano silica are still very uncertain.
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